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決定的進化の軌跡が原発腫瘍の成長に影響する:TRACERx腎
Samra Turajlic1, Hang Xu2, Kevin Litchfield2
1Translational Cancer Therapeutics Laboratory, the Francis Crick Institute, London NW1 1AT, UK; Renal and Skin Units, the Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.
Cell
|April 17, 2018
まとめ
この研究では,クリアセル腎臓細胞癌 (ccRCC) の7つの異なる進化的サブタイプが明らかになり,遺伝的多様性と染色体複雑性が患者のアウトカムに関連し,バイオマーカーとしての進化的可能性を示唆しています.
科学分野:
- 腫瘍学
- 進化生物学
- ゲノミクス
背景:
- クリア・セル腎臓がん (ccRCC) の進化はあまり研究されていない.
- ccRCCの進化パターンを理解することは,臨床行動の予測に不可欠です.
研究 の 目的:
- ccRCCの進化的特徴を体系的に分析する.
- 進化的サブタイプと患者の予後との関連を特定する.
主な方法:
- TRACERx腎臓研究における101人のCCRCC患者の1206の原発腫瘍領域の分析
- クローンレベルでドライバーイベントの順番,同時発生,相互排他性の詳細な検討.
主要な成果:
- 予後パラメータに関連したサブクローン多様化で,腫瘍ごとに最大30のドライバイベントが観察されました.
- 急速に転移する腫瘍から広範な並行進化の腫瘍まで,七つのccRCCの進化サブタイプを特定した.
- 遺伝的多様性と染色体の複雑性は,患者の結果の重要な決定因子として特定されました.
結論:
- ccRCCの進化的サブタイプは,変化する臨床行動を説明します.
- 進化的可能性は,CCRCCの介入と監視戦略のバイオマーカーとして役立つ.
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