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関連する概念動画

Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

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Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
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Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
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Random and Systematic Errors

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Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
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Systematic Sampling Method01:17

Systematic Sampling Method

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Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
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Propagation of Uncertainty from Systematic Error01:10

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The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
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A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
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A Hydroponic Co-cultivation System for Simultaneous and Systematic Analysis of Plant/Microbe Molecular Interactions and Signaling
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複雑な遺伝子相互作用の体系的分析

Elena Kuzmin1,2, Benjamin VanderSluis3, Wen Wang3

  • 1The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

Science (New York, N.Y.)
|April 21, 2018
PubMed
まとめ
この要約は機械生成です。

研究者は酵母菌のトリプルミュータントを作り 複雑な遺伝子相互作用をマッピングしました 彼らはこれらのトライジェニックの相互作用が 遠く離れた生物学的過程を結びつけていることが分かっていますが それは以前考えられていたよりもずっと広範囲に及ぶのです

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科学分野:

  • 遺伝学
  • システム生物学
  • 酵母遺伝学

背景:

  • 複雑な遺伝子の相互作用を理解することは,遺伝と遺伝子型とフェノタイプの関係を解読するのに不可欠です.
  • 以前の研究は主に二遺伝子 (二遺伝子) 相互作用に焦点を当て,より高いレベルの相互作用はほとんど調査されていない.

研究 の 目的:

  • 酵母トリプルミュータントの構築と分析によって複雑な遺伝的相互作用を体系的に調査する.
  • 大規模な遺伝子ネットワーク内の負の三遺伝子相互作用の風景と特性を特徴づける.

主な方法:

  • 約20万の酵母トリプルミュータントの構築
  • 多様な生物学的過程における負の三遺伝子相互作用のスコア付け
  • 遺伝子の機能的関係とネットワークトポロジーの分析

主要な成果:

  • トライジェニックの相互作用には,しばしば機能的に関連した遺伝子があり,重要な遺伝子はネットワークのハブとして機能します.
  • これらの相互作用は,遠隔の生物学的プロセスから遺伝子を繋ぐことが多く,ディジェニックの相互作用よりも弱い大きさを示します.
  • グローバル・トライジェニック・インタラクション・ネットワークは,ディジェニック・ネットワークより約100倍大きいと推定されている.

結論:

  • 複雑な遺伝子相互作用,特にトライジェニックは,生物学的遺伝において重要な役割を果たします.
  • トライジェニックネットワークの広さは,以前よりもフェノタイプに影響を与えるより複雑な遺伝子構造を示唆しています.
  • ゲノタイプとフェノタイプの関係を完全に理解するために,より高いレベルの遺伝的相互作用のさらなる探求が必要である.