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Updated: Feb 11, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
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Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

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MFN2アゴニストは,シャルコ・マリー・トゥース病2A型の前臨床モデルにおけるミトコンドリア欠陥を逆転させる

Agostinho G Rocha1, Antonietta Franco1, Andrzej M Krezel2

  • 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Science (New York, N.Y.)
|April 21, 2018
PubMed
まとめ

新しいミトフーシンアゴニストはミトコンドリア融合を活性化し,シャルコ・マリー・トゥース病2A型 (CMT2A) モデルの欠陥を修正する. このアプローチは,ミトコンドリア機能障害に関連した神経変性疾患の治療の可能性を提供します.

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