宿主防衛を超えて: 複雑な組織生理学的制御における免疫系の新興機能
Lucille C Rankin1, David Artis1
1Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, and Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Cell
|April 21, 2018
まとめ
免疫系は病原菌と戦うだけでなく 神経系と食事からの信号を感知して 全身の機能を調節し ホメオスタシスを維持します
科学分野:
- 免疫学
- 神経科学
- メタボリック研究
背景:
- 免疫系は自己と非自己を区別し 病原体や腫瘍から防御するために 極めて重要です
- 詳細な分子と細胞のネットワークが 宿主防御と病原体の駆逐に 備わっています
- 免疫細胞は 病原菌以外の様々な信号を 感知していることが 明らかになっています
研究 の 目的:
- 免疫系と他の器官系との相互作用の統合的な見方を提案する.
- 組織や環境からの信号に 免疫系がどう反応するかを調べる
- 組織と全身のホメオスタシスを維持する 免疫系の役割を理解する
主な方法:
- このレビューは,免疫系のシグナル伝達に関する現在の研究をまとめています.
- 免疫学,神経科学,代謝研究からの発見を統合しています.
- 臓器間のコミュニケーションと ホメオスタティックな調節に重点を置いています
主要な成果:
- 免疫細胞は神経系と食事から信号を感知します
- これらの相互作用は,代謝や発熱などの生理学的プロセスに影響を与えます.
- 免疫系は神経系機能と組織修復の調節に積極的に参加する.
結論:
- 免疫系は様々な信号を感知し 統合する上で重要な役割を果たします
- 免疫系と他の器官系との交響は,ホメオスタシスにとって不可欠です.
- 免疫系を全身の生理学の中心的調節体として見ることが必要です
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