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Updated: Feb 11, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

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薬剤耐性における lncRNA を機能化する全ゲノム CRISPRa アプローチ

Assaf C Bester1, Jonathan D Lee1, Alejandro Chavez2

  • 1Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.

Cell
|April 21, 2018
PubMed
まとめ

この研究では,がん薬剤耐性に影響を与える遺伝子を発見するための新しいCRISPRスクリーニングプラットフォーム (DICaS) が導入されています. AMLにおける化学療法抵抗に寄与するGAS6-AS2 lncRNAを含む新しい細胞サイクル,生存,シグナル伝達遺伝子を特定した.

キーワード:
AML についてAXL/GAS6 についてCRISPRについてCRISPRaについてTEM癌についてシタラビン薬剤耐性について白血病についてlncRNA について

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