関連する実験動画

Updated: Feb 11, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

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核輸入受容体は,複数の場所への結合により,FUSの相分離を阻害する

Takuya Yoshizawa1, Rustam Ali2, Jenny Jiou1

  • 1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|April 21, 2018
PubMed
まとめ

カリオフェリンβ2は,FUSタンパク質のPY-NLSと結合することによって,液体-液体相分離 (LLPS) を阻害する. この相互作用はFUSの自己組み立てを妨害し,コンデンサートの形成と調節に関する洞察を提供します.

キーワード:
FUS についてPY-NLS についてRNAの粒アミオトロフィック・ラテラル・スクレロス生物分子凝縮物本質的に無秩序なタンパク質カリオフェリン-β2液体-液体相分離複雑性が低いシーケンストランスポートイン-1

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