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Updated: Feb 11, 2026

In vitro Methylation Assay to Study Protein Arginine Methylation
10:01

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Published on: October 5, 2014

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FUSの相分離は,その核輸入受容体とアルギニンメチル化によって抑制される

Mario Hofweber1, Saskia Hutten2, Benjamin Bourgeois3

  • 1Biomedical Center (BMC), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany.

Cell
|April 21, 2018
PubMed
まとめ

トランスポートインとアルギニンのメチル化は,前頭葉性認知症 (FTD) と筋縮性横筋硬化症 (ALS) でFUSタンパク質の結合を防ぐ. これらのプロセスの障害は,FUS液相分離とストレス粒子の結合を促進し,神経変性に寄与します.

キーワード:
ALS についてFTD についてカリオフェリン-β2 (Kapβ2)トランスポートイン (TNPO1)アルギニンメチル化サルコマに溶けた (FUS)神経変性核の輸入フェーズ分離ストレス・グランブル

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