GPR68 は 感覚 の 流れ に 役立ち,血管 生理 に 欠かせ ない
Jie Xu1, Jayanti Mathur1, Emilie Vessières2
1Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
Cell
|April 21, 2018
まとめ
研究者らは,Gタンパク質結合受容体68 (GPR68) を,内皮細胞における血流の重要なセンサーとして特定した. この発見は高血圧や動脈硬化などの 血管疾患の理解に 極めて重要です
科学分野:
- 血管生物学
- 機械生物学
- 心血管の生理学
背景:
- メカノトランスダクションは血管生物学において重要であり,フローメディエイトドディレーション (FMD) を通して血管抵抗を調節する.
- 乳房内膜機能障害は 乳房内膜機能不全によって示され 高血圧や動脈硬化などの血管疾患に先行する.
- 内皮細胞のシアストレスを感知する特定の分子はほとんど特定されていません.
研究 の 目的:
- 内皮細胞における切断ストレスを感知する分子機構と特定の分子を特定する.
- 流動媒介による膨張と血管再構築における 特定された分子の役割を調査する.
主な方法:
- 培養細胞のための384井戸の切断ストレススクリーニングシステムを開発した.
- 機械感受性細胞系を用いて 切断ストレスで活性化されたカルシウムトランジエントを検出した
- 焦点のRNAiライブラリをスクリーニングし,シアストレスの反応に重要な遺伝子を特定しました.
- ネズミの中腔動脈のGPR68発現を調べた.
- Gpr68欠乏したマウスの口腔炎と血管再構築を評価した.
主要な成果:
- Gタンパク質結合受容体68 (GPR68) は,内皮細胞における切断ストレス反応に必要かつ十分であると特定された.
- GPR68は小径抵抗動脈の内皮細胞で発現する.
- Gpr68欠乏したマウスは,急性口腔炎と慢性的なフローメディエートされた外側再構成が著しく低下した.
- GPR68は動脈内皮における重要な流れセンサーとして機能する.
結論:
- GPR68は,動脈内皮のシアストレスを感知するための重要な分子成分です.
- GPR68は,心臓血管病理学,特に血管抵抗と再構成の調節において重要な役割を果たします.
- GPR68を標的とした治療は,内皮機能障害に関連した血管疾患に対する新しい治療戦略を提供することができる.
関連する概念動画
01:25Compounds Essential to Human Function
10.5K
The human body is composed of cells that are fundamentally made up of several different molecules. These molecules are essential to carry out all physiological processes in the body and are broadly classified into organic and inorganic based on their chemical structures.
Inorganic Compounds Essential to Human Functioning
Inorganic compounds essential to human functioning include water, salts, acids, and bases. These compounds are inorganic, i.e., they do not have a carbon-hydrogen bond. Water...
Inorganic Compounds Essential to Human Functioning
Inorganic compounds essential to human functioning include water, salts, acids, and bases. These compounds are inorganic, i.e., they do not have a carbon-hydrogen bond. Water...
10.5K
02:57The Sense of Self: Reflected Self-Appraisal and Social Comparison
56.1K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.1K
01:29Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration
965
The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
965
01:31Essential Minerals for Bone Health
6.6K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.6K
03:24Seedless Vascular Plants
67.7K
Seedless Vascular Plants Were the First Tall Plants on Earth
67.7K
01:26Introduction to Special Senses
7.7K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
7.7K