分離可能な構造的および機能的ヒポカンプス出力
Mark S Cembrowski1, Matthew G Phillips1, Salvatore F DiLisio1
1Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Dr., Ashburn, VA 20147, USA.
Cell
|April 24, 2018
まとめ
海馬は背中の垂直部分に 異なる並列回路を含み 空間的な作業記憶に影響を与えます これらの回路は 分子,細胞,機能の違いを示し 脳機能の特殊な経路を明らかにします
科学分野:
- 神経科学
- 分子生物学
- 認知科学
背景:
- 哺乳類の海馬は 認知と行動に不可欠です
- その機能的多様性は,潜在的にサブフィールド内の並列回路によって説明されます.
- 背面の亜皮質は背面の海馬の主要な出力である.
研究 の 目的:
- 背面の皮の並列回路を特定し,描写し,操作する.
- サビキュラム内の機能的専門化の分子と細胞の基礎を調査する.
- 空間的な作業メモリにサブスクーラーサブリージョンの差異的な貢献を決定する.
主な方法:
- 遺伝子発現に基づくサブリージョンを特定するための集団と単細胞RNAシーケンシング.
- ニューロンの入力,局所配線,プロジェクションターゲット,および電気生理学の分析.
- 機能的な貢献を評価するために 遺伝的に制限されたニューロンの沈黙
主要な成果:
- 背中のサブキュラムは,ピラミッド細胞の遺伝子発現を特徴とする空間的に隣接する2つのサブ領域に分割された.
- これらの亜領域はニューロンの接続性と電気生理学的性質の違いを示した.
- これらのサブリージョンの選択的な静止は,空間的な作業記憶におけるそれらの異なる役割を示した.
結論:
- ヒッポキャンプスは 構造的にも機能的にも 異なる並列の流れを シリアルアーキテクチャに組み込んでいます
- これらの発見は,ヒポカンプスの専門性に関する 分子,細胞,回路,および行動的理解を提供します.
- 脊髄の並列回路は 空間的な作業記憶の能力に寄与します
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