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Nuclear Transmutation03:20

Nuclear Transmutation

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed protons being...
Conversion of Units01:36

Conversion of Units

Sometimes, there is a need to convert from one unit to another one. For instance, reading a cookbook in which quantities are expressed in units of liters or ounces may require conversion of quantities to cups. Or, when looking up directions on how to get to a location, we may be interested to know how many miles we are going to walk. In this case, we would have to convert units of feet or meters to miles.
The first step in the unit conversion is to list the given units and the units required...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Transformers in Distribution System01:27

Transformers in Distribution System

Transformers in distribution systems can be broadly categorized into distribution substation transformers and other distribution transformers. They are crucial for stepping down high transmission voltages to levels suitable for distribution and end-user applications.
Distribution substation transformers come in various ratings and typically use mineral oil for insulation and cooling. To prevent moisture and air from entering the oil, some transformers use an inert gas like nitrogen to fill the...
Transformers with Off-Nominal Turns Ratios01:25

Transformers with Off-Nominal Turns Ratios

In scenarios involving parallel transformers with disparate ratings, developing per-unit models requires accommodating off-nominal turns ratios. This situation arises when the selected base voltages are not proportional to the transformer’s voltage ratings. Consider a transformer where the rated voltages are related by the term a. If the chosen voltage bases satisfy a relationship involving term b, term c is defined as the ratio of these bases. This ratio is then substituted into the rated...

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Updated: Jun 24, 2026

Capture Compound Mass Spectrometry - A Powerful Tool to Identify Novel c-di-GMP Effector Proteins
12:11

Capture Compound Mass Spectrometry - A Powerful Tool to Identify Novel c-di-GMP Effector Proteins

Published on: March 29, 2015

ラムダ・クローをトランスクリプションアクティベーターに変換する.

F D Bushman1, M Ptashne

  • 1Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.

Cell
|July 15, 1988
PubMed
まとめ
この要約は機械生成です。

ラムダ抑制剤は,RNAポリメラーゼと相互作用することによって転写を活性化します. 研究者は,この"活性化パッチ"をCroタンパク質に転送し,新しい転写活性化剤を作り,活性化に十分であることを実証しました.

さらに関連する動画

Automated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)
09:24

Automated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)

Published on: December 18, 2020

Laboratory Scale Slow Cook-Off Testing of Rocket Propellants: The Combustion Rate Analysis of a Slowly Heated Propellant (CRASH-P) Test
06:52

Laboratory Scale Slow Cook-Off Testing of Rocket Propellants: The Combustion Rate Analysis of a Slowly Heated Propellant (CRASH-P) Test

Published on: February 6, 2021

関連する実験動画

Last Updated: Jun 24, 2026

Capture Compound Mass Spectrometry - A Powerful Tool to Identify Novel c-di-GMP Effector Proteins
12:11

Capture Compound Mass Spectrometry - A Powerful Tool to Identify Novel c-di-GMP Effector Proteins

Published on: March 29, 2015

Automated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)
09:24

Automated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT)

Published on: December 18, 2020

Laboratory Scale Slow Cook-Off Testing of Rocket Propellants: The Combustion Rate Analysis of a Slowly Heated Propellant (CRASH-P) Test
06:52

Laboratory Scale Slow Cook-Off Testing of Rocket Propellants: The Combustion Rate Analysis of a Slowly Heated Propellant (CRASH-P) Test

Published on: February 6, 2021

科学分野:

  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは
  • バイオケミストリー バイオケミストリー

背景:

  • DNAに結合するラムダ抑制剤は,RNAポリメラーゼとの相互作用によって転写を刺激する.
  • 変異分析により,トランスクリプション活性化に不可欠なラムダ抑制器の酸性パッチが特定されました.

研究 の 目的:

  • ランバダ抑制剤の特定された"活性化パッチ"が転写活性化に十分であるかどうかを判断する.
  • この活性化パッチが他のタンパク質やファグで果たす役割を調査する.

主な方法:

  • 転写活性化に障害があるラムダ抑制剤変異体の分離.
  • "活性化パッチ"をラムダ・リプレッサーからラムダ・クロータンパク質に転送する.
  • 改造されたCroタンパク質の転写活性を分析する.

主要な成果:

  • ラムダ抑制体の"活性化パッチ"は,新しい配列の文脈で転写活性化に十分であることが判明しました.
  • 抑制器の活性化パッチを含む改造されたラムダ・クロータンパク質は,転写活性化剤の特性を示した.
  • 証拠によると,ファグ434抑制体は,転写のために同様の活性化パッチを使用している.

結論:

  • ラムダ抑制器の酸性"活性化パッチ"は,転写活性化のための重要な機能領域である.
  • この活性化パッチは,他のタンパク質に転写活性化能力を授与することができます.
  • 似たような活性化パッチを含むトランスクリプション活性化の保存されたメカニズムは,異なるファグ抑制体間で存在することがあります.