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Updated: Feb 11, 2026

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
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Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Published on: August 27, 2021

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ダイナミック・コヴァレンント・バインディング・モチーフのファージ表示は,標的型抗生物質の開発を容易にする

Kelly A McCarthy1, Michael A Kelly1, Kaicheng Li1

  • 1Department of Chemistry, Merkert Chemistry Center , Boston College , Chestnut Hill , Massachusetts 02467 , United States.

Journal of the American Chemical Society
|April 28, 2018
PubMed
まとめ

新しいファグディスプレイプラットフォームは,特定の細菌株のペプチドプローブを迅速に特定し,抗生物質耐性の増大と戦うために標的の抗生物質開発と診断を可能にします. このアプローチは,Staphylococcus aureusやAcinetobacter baumanniiのような耐性病原体に対する狭いスペクトルの治療法を開発するのに役立ちます.

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