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プリミRNA基質によるヒトDicerとその複合体の冷凍-EM構造

Zhongmin Liu1, Jia Wang1, Hang Cheng2

  • 1Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China 100084.

Cell
|May 1, 2018
PubMed
まとめ

ヒューマン・ディサー (hDicer) とその共同因子TRBPは,ミクロRNA前構造を安定させる. これらの発見は,hDicerによるRNA干渉 (RNAi) と遺伝子静止のメカニズムを明らかにする.

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