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Updated: Feb 11, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
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GPCR媒介によるアストリン活性化の分子機構

Naomi R Latorraca1,2,3,4, Jason K Wang2, Brian Bauer5

  • 1Biophysics Program, Stanford University, Stanford, CA, USA.

Nature
|May 4, 2018
PubMed
まとめ

Gタンパク質結合受容体 (GPCR) がアストリンを活性化させる方法を発見することは,薬剤設計の鍵です. この研究は,受容体の核と尾の両方がアストリンを独立して活性化することを明らかにし,バイアスされたGPCRリガンド開発に関する新しい洞察を提供します.

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