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関連する概念動画

Isotopes01:12

Isotopes

64.9K
Elements have a set number of protons that determines their atomic number (Z). For example, all atoms with eight protons are oxygen; however, the number of neutrons can vary for atoms of the same element. The sum of the number of protons and the number of neutrons is the mass number (A). Atoms with the same atomic number but different mass numbers are called isotopes. Elements can have multiple isotopes, for example, carbon-12, carbon-13, and carbon-14.
An element's atomic mass, or weight,...
64.9K
Elements: Chemical Symbols and Isotopes02:31

Elements: Chemical Symbols and Isotopes

127.0K
A chemical symbol is an abbreviation used to indicate an element or an atom of an element. For example, the symbol for mercury is Hg. The same symbol is used to indicate one atom of mercury (microscopic domain) or to label a container of many atoms of the element mercury (macroscopic domain).
Some symbols are derived from the common English name of the element; others are abbreviations of the name in another language — Latin, Greek or German. For example, the symbol for aluminum (common name)...
127.0K
Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

12.9K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
12.9K
Mass Spectrometry: Isotope Effect01:13

Mass Spectrometry: Isotope Effect

4.3K
Most elements exist in nature as a mixture of isotopes. The isotopes differ in weight due to their respective number of neutrons. The molecular weight of a molecule is different depending on the specific isotope of its elements involved. As a result, the mass spectrum of the molecule exhibits peaks from the same fragment at multiple positions. The positions of these mass signals depend on the mass differences between isotopes. Furthermore, the intensity of these signals is dependent on the...
4.3K
Atomic Mass01:52

Atomic Mass

70.4K
Atoms — and the protons, neutrons, and electrons that compose them — are extremely small. For example, a carbon atom weighs less than 2 × 10−23 g. When describing the properties of tiny objects such as atoms, we use appropriately small units of measure, such as the atomic mass unit (amu). The amu was originally defined based on hydrogen, the lightest element, then later in terms of oxygen. Since 1961, it has been defined with regard to the most abundant isotope of carbon, atoms of which...
70.4K
Radioactivity and Nuclear Equations03:18

Radioactivity and Nuclear Equations

27.5K
Nuclear chemistry is the study of reactions that involve changes in nuclear structure. The nucleus of an atom is composed of protons and, except for hydrogen, neutrons. The number of protons in the nucleus is called the atomic number (Z) of the element, and the sum of the number of protons and the number of neutrons is the mass number (A). Atoms with the same atomic number but different mass numbers are isotopes of the same element.
A nuclide of an element has a specific number of protons and...
27.5K

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関連する実験動画

Updated: Feb 11, 2026

Author Spotlight: Quantification of Complex Lipidomic Samples Using Stable Isotope Labeling
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Author Spotlight: Quantification of Complex Lipidomic Samples Using Stable Isotope Labeling

Published on: August 23, 2024

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メタボロミクスとイソトープトレーシング

Cholsoon Jang1, Li Chen1, Joshua D Rabinowitz1

  • 1Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Washington Rd, Princeton, NJ 08544, USA.

Cell
|May 5, 2018
PubMed
まとめ

質量スペクトロメトリ (MS) は,代謝を研究するための代謝物の同時測定を可能にします. MSと安定した同位体の追跡を組み合わせると 代謝経路の活動が明らかになり 生物学的過程が解明されます

科学分野:

  • 生物化学
  • メタボロミクス
  • システム生物学

背景:

  • 代謝は生物学的システムを理解するために不可欠です
  • 質量スペクトロメトリ (MS) は代謝物測定に革命をもたらしました.
  • 安定した同位体追跡は,代謝経路の動態に関する洞察を提供します.

研究 の 目的:

  • MSを用いたメタボライト測定の基本原理を概説する.
  • メタボロミクスと同位体追跡の 組み合わせの力を示すために
  • 生物学的研究におけるこれらの技術の応用を強調する.

主な方法:

  • MSベースのメタボロミック分析のためのサンプル準備
  • 総合的なメタボロミックプロファイリングを行う.
  • 安定した同位体トレーサーを使って 代謝の流れを追跡する
  • メタボロミックと同位体データのデータ解釈戦略

主要な成果:

  • 多発性硬化症では,多数の代謝物の同時測定が可能である.
  • アイソトープトラッキングは 代謝経路の活動を効果的に明らかにします
  • 統合されたメタボロミクスと同位体追跡は 深い生物学的な洞察を提供します

さらに関連する動画

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing
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A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing

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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

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関連する実験動画

Last Updated: Feb 11, 2026

Author Spotlight: Quantification of Complex Lipidomic Samples Using Stable Isotope Labeling
07:12

Author Spotlight: Quantification of Complex Lipidomic Samples Using Stable Isotope Labeling

Published on: August 23, 2024

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A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing
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A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing

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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
07:34

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

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結論:

  • MSベースのメタボロミクスは 生物学的発見のための強力なツールです
  • メタボロミクスを同位体追跡と組み合わせることで,代謝ネットワークの理解が向上します.
  • これらの統合されたアプローチは,生物学的研究を進めるために不可欠です.