コルチコアミグダラ 社会的情報伝達 ゲート 観察学習
Stephen A Allsop1, Romy Wichmann1, Fergil Mills1
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell
|May 8, 2018
まとめ
ネズミは他の動物を観察することで 脅威を認識します この過程には前帯状皮質 (ACC) と桃体 (BLA) が関与します ACCからBLAへの経路は この観察恐怖条件付けの獲得に不可欠です
科学分野:
- 神経科学
- 行動科学
- 学習 と 記憶
背景:
- 観察学習により 直接的な処罰なしに 脅威を回避する戦略を身につけることができます
- 前帯状皮質 (ACC) と基礎側桃体 (BLA) は社会的恐怖の学習に関与している.
- ACC-BLA回路内の情報フローを理解することは,観察恐怖を説明する鍵です.
研究 の 目的:
- 観察による恐怖の条件付けで 情報の暗号化と伝達の 神経機構を調査する.
- BLA (ACC→BLA) へのACC予測が社会的な脅威の学習における役割を決定する.
主な方法:
- 電気生理学的記録は,恐怖条件付けを受けたデモンストレーターマウスを観察するマウスで行われました.
- ACC→BLA投影の選択的阻害は,その因果的役割を評価するために使用されました.
- アミグダラの神経表現は,観察条件付けで監視された.
主要な成果:
- ACC→BLAニューロンは,社会的に派生した嫌悪感に関する情報を優先的にコードします.
- ACC→BLAの阻害は,観察中にアミグダラの嫌悪感の表象を変化させた.
- ACC→BLAの選択的抑制は,観察的な恐怖の獲得を妨げましたが,表現はしませんでした.
結論:
- キューの嫌悪値に関する情報は,観察学習によってACCからBLAに伝達される.
- ACC→BLA経路は,観察を通して恐怖を習得するために非常に有益です.
- この研究は 社会的脅威を学ぶための 神経回路を明らかにしています
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