構成要素のJ-およびH-アグリゲーションによる2つの構成要素のヒドロゲルの超分子キラリティの制御

Guofeng Liu¹, Jianhui Sheng^1,2, Hongwei Wu¹

¹Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences , Nanyang Technological University , 21 Nanyang Link , 637371 , Singapore.

Journal of the American Chemical Society

|May 8, 2018

まとめ

研究者はフェニララニンベースの分子とアキラル添加物を用いて調節可能な螺旋型のナノ構造を作り出した. この突破は超分子キラリティの洞察を提供しキラルナノ構造の正確な製造を可能にします

科学分野:

超分子化学
材料科学
チラリティ研究

背景:

ナノ構造のヘリシティを操作することは難しいことですがヘリカルなシステムを理解するには不可欠です
セルフアセンブリにおける超分子キラリティの起源を理解することは重要な研究分野です.
J-およびH-集積のような機能性指向のスタッキングモードは,ナノ構造のキラリティに影響します.

研究の目的:

セルフアセンブリにおける超分子キラリティの起源と制御を調査する.
調節可能な性質を持つ螺旋型のナノファイバーを作成する方法を開発する.
ヘリックス逆転におけるブロック集積の役割を探求する.

主な方法:

フェニララニン基のエナンチオマーとアキラルビス (ピリジニル) デリバティブを用いた2組の水素ゲルの製造.
螺旋状のナノファイバーを形成するブロックのステキオメトリックの組み立て.
円形二重化,スキャニング電子顕微鏡,フーリエ変換赤外線光譜,単一X線結晶学を用いた特徴付け.

主要な成果:

逆ハンドネス,制御可能なピッチ,直径を持つ螺旋型のナノファイバーが成功裏に合成されました.
ヘリックス逆転は,ビス (ピリジニル) 誘導体のJとH結合モードの間の移行によって達成された.
逆ハンド性は,エナティオメリック構成要素を使用するか,同じ構成のキラルモノマーとアキラル添加物を交換することによって得られた.

結論:

この研究は,分子自己組み立てにおける起源とヘリシティの逆転メカニズムを明らかにしている.
チラルナノ構造の精密な製造のための経路を提供します.
スマートディスプレイデバイス,光電子機器,および生物学的システムにおける潜在的な応用を強調しています.

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