Redox-Active AIEgen-Derived Plasmonic and Fluorescent Core@Shell ナノ粒子は,マルチモダリティのバイオイメージングのために使用されている
Xuewen He1,2, Zheng Zhao1,2, Ling-Hong Xiong1,2,3
1Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Institute for Advanced Study, Division of Life Science, and Division of Biomedical Engineering , The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon , Hong Kong.
Journal of the American Chemical Society
|May 10, 2018
まとめ
研究者は,高度な多様性イメージングのための新しいシルバーコア@集積誘発発光素 (AIEgen) シェルナノ粒子 (AACSNs) を開発しました. これらのナノ粒子は光解消を克服し 細胞や動物の画像を 強化できます
科学分野:
- ナノテクノロジー
- バイオメディカルイメージング
- 材料科学
背景:
- マルチモダリティ画像は 感度,解像度,深さの組み合わせにより 優れた診断精度を提供します.
- 光とプラズモンの統合は,金属ナノ粒子が光を消すため困難です.
研究 の 目的:
- 多様性イメージングのための光とプラズモニック特性を統合した新しいコアシェルナノ粒子を開発する.
- 光物質とプラズモンの不適合性を克服する
主な方法:
- 合成された銀@AIEgenコア・シェルナノ粒子 (AACSNs) は,リドックス反応による.
- 聚合誘発放射ルミノゲン (AIEgen) を光と銀ナノ粒子をプラズモンの特性のために利用した.
- 生体細胞と小動物モデルでのナノ粒子性能の評価
主要な成果:
- AACSNは強い集積状態の光と明確なプラズモンの散乱を示した.
- 光イメージング,ダークフィールド顕微鏡,X線コンピュータトモグラフィーで高性能を達成しました.
- AACSNは良好な生物適合性と環境安定性を示した.
結論:
- 開発されたAACSNは,多様性イメージングに有効であり,光解消問題を克服します.
- これらのナノ粒子は in vivo 診断と生物学的研究に 大きな可能性を秘めています
- 協同的なコアシェルの設計は,高度なイメージングアプリケーションのための多用途のプラットフォームを提供します.
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