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Updated: Feb 10, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

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分割されたNAD+バイオシンセシスによる転写の代謝調節

Keun Woo Ryu1,2,3, Tulip Nandu1,2, Jiyeon Kim4

  • 1Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Science (New York, N.Y.)
|May 12, 2018
PubMed
まとめ

ニコチナミドアデニンジヌクレオチド (NAD+) 合成区分化は,グルコース代謝と脂肪細胞の分化を統合する. NMNAT-2による細胞質NAD+合成は,核NAD+を低下させ,PARP-1を阻害し,アディポゲネシスを誘発する.

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