左心室付属体の閉塞後の器具関連の血栓:発生率,予測要因,結果
PubMedで要約を見る
まとめ
この要約は機械生成です。装置関連の血栓 (DRT) は,ウォッチマン左心房閉塞後の約3. 7%の患者で発生する. DRTは稀ですが,脳卒中や全身栓塞のリスクを大幅に高め,慎重にモニタリングする必要があります.
科学分野
- 心臓病科
- 医療機器
- トロンボシス 研究
背景
- ウォッチマン装置で左心房の閉塞を施した心房細動の患者は,装置関連の血栓 (DRT) のリスクがあります.
- ウォッチマン装置のDRT形成は,潜在的に血栓塞栓的事件につながる可能性があります.
- DRTの発生率,予測要因,結果を理解することは 患者の管理に不可欠です.
研究 の 目的
- 装置関連の血栓 (DRT) の発生率,予測要因,および臨床結果を調査する.
- 複数の臨床試験でウォッチマン移植を受けた患者のDRTを分析する.
- DRTと術後の脳卒中または全身栓塞 (SSE) の関連性を評価する.
主な方法
- PROTECT- AF,PREVAIL,CAP,CAP2を含む4つの将来的な食品医薬品局 (FDA) 試験の分析
- 植入後45日,6ヶ月,そして12ヶ月で実施された監視性食道横断エコーカルジオグラム.
- CHA2DS2-VASCとHAS-BLEDのスコアに調整したDRT発生率と臨床結果の評価.
主要な成果
- 1739人の患者の3. 74%にDRTが観察され,SSEの発生率は100患者年あたり7. 46で,DRTを受けていない患者と比較して100患者年あたり1. 78であった.
- DRTの予測因子には,短期間性缺血発作や脳卒中,永久性心房細動,血管疾患,左心房付属体の直径の拡大,左心房下部放出分子が含まれる.
- DRTとSSEは,DRT患者の26. 2%で同時に発生し,SSEイベントの有意な割合はDRTの検出から6ヶ月以内に発生しました.
結論
- 装置関連の血栓 (DRT) は約3. 7%の患者で発生する.
- DRTの存在は,脳卒中と全身栓塞のリスクの増加と有意に関連しています.
- DRTは頻繁ではないが,不良の血栓塞栓事件と関連しているため,慎重に検討する必要があります.
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