大腸がんの分類のためのコンセンサスのImmunoscoreの国際的検証:予測と精度に関する研究

Franck Pagès ¹, Bernhard Mlecnik ², Florence Marliot ¹

¹INSERM, Laboratory of Integrative Cancer Immunology, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France; Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France.
²INSERM, Laboratory of Integrative Cancer Immunology, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France; Inovarion, Paris, France.
³INSERM, Laboratory of Integrative Cancer Immunology, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France.
⁴Cancer Center Statistics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
⁵Department of Pathology, Providence Portland Medical Center, Portland, OR, USA.
⁶Institute of Pathology, University of Bern, Bern, Switzerland.
⁷Department of Medical Oncology, University Hospital of Bern, Bern, Switzerland.
⁸Pathology Department, Radboud University, Nijmegen, Netherlands.
⁹Department of Pathology, University Erlangen-Nürnberg, Erlangen, Germany.
¹⁰Department of Surgery, University Erlangen-Nürnberg, Erlangen, Germany.
¹¹Institut Roi Albert II, Department of Medical Oncology Cliniques Universitaires St-Luc, Brussels, Belgium; Institut de Recherche Clinique et Experimentale (Pole MIRO), Université Catholique de Louvain, Brussels, Belgium.
¹²Department of Pathology, Cliniques Universitaires St-Luc, Brussels, Belgium; Institut de Recherche Clinique et Experimentale (Pole GAEN), Université Catholique de Louvain, Brussels, Belgium.
¹³Institut Roi Albert II, Department of Digestive Surgery, Cliniques Universitaires St-Luc Université Catholique de Louvain, Brussels, Belgium.
¹⁴Curandis Laboratories, Boston, MA, USA; Department of Pathology and Laboratory Medicine, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
¹⁵Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
¹⁶Department of Pathology and Laboratory Medicine, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹⁷University Health Network, Toronto, ON, Canada.
¹⁸Department of Pathology and Laboratory Medicine, University Health Network, Toronto, ON, Canada.
¹⁹Department of Oncology-Pathology, Karolinska Institutet, Karolinska University, Stockholm, Sweden.
²⁰Department of Oncology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
²¹Institute of Pathology, First Faculty of Medicine, Charles University, Prague, Czech Republic; General University Hospital in Prague, Prague, Czech Republic.
²²Department of Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G.Pascale" Naples, Italy.
²³Colorectal Surgery Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G.Pascale" Naples, Italy.
²⁴IRCCS Istituto Nazionale Tumori "Regina Elena", Rome, Italy.
²⁵Center for Immuno-Oncology, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy.
²⁶Molecular Gastroenterology and Department of Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
²⁷Molecular Gastroenterology and Department of Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy; Humanitas University, Rozzano, Milan, Italy.
²⁸INSERM, Laboratory of Integrative Cancer Immunology, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France; NanoString Technologies, Seattle, WA, USA.
²⁹INSERM, Laboratory of Integrative Cancer Immunology, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France; Translational Science, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
³⁰Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France.
³¹INSERM, Laboratory of Integrative Cancer Immunology, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France; Digestive Surgery Department, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France.
³²Laboratory of Molecular and Tumor Immunology, Earle A. Chiles Research Institute, Robert W Franz Cancer Center, Providence Portland Medical Center, Portland, OR, USA.
³³University of Medicine and Pharmacy "Grigore T. Popa" Iaşi, Department of Surgical Oncology, Regional Institute of Oncology, Iaşi, Roumania.
³⁴Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
³⁵Department of Translational Research and Developmental Therapeutics against Cancer, Yamaguchi University School of Medicine, Yamaguchi, Japan.
³⁶Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
³⁷Department of Surgery, Kindai University, School of Medicine, Osaka-sayama, Japan.
³⁸Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
³⁹Department of Surgery, Surgical Oncology, and Science, Sapporo Medical University School of Medicine, Sapporo, Japan.
⁴⁰Department of Immunology and Immunotherapy, Kurume University School of Medicine, Kurume, Japan.
⁴¹The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad, India.
⁴²Institute for Cancer Research of School of Basic Medical Science, Department of Pathology of the First Affiliated Hospital, Health Science Center of Xi'an Jiaotong University, Xian, China.
⁴³Research Branch, Sidra Medical and Research Centre, Doha, Qatar.
⁴⁴Melanoma, Cancer Immunotherapy and Innovative Therapies Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione "G. Pascale", Napoli, Italy.
⁴⁵Laboratory of Molecular and Tumor Immunology, Earle A. Chiles Research Institute, Robert W Franz Cancer Center, Providence Portland Medical Center, Portland, OR, USA; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA.

⁰INSERM, Laboratory of Integrative Cancer Immunology, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Sorbonne Universités, Paris, France; Immunomonitoring Platform, Laboratory of Immunology, AP-HP, Assistance Publique-Hopitaux de Paris, Georges Pompidou European Hospital, Paris, France.

イムノスコア検査は大腸がんの再発リスクを正確に予測しますこの免疫スコアはT細胞を定量化し癌の分類と患者の予後を改善し臨床的実施を支援します

科学分野

腫瘍学
免疫学
病理学について

背景

大腸がんの再発リスクを推定するには改善された方法が必要です
免疫細胞の浸透を定量化することは癌の分類に不可欠です
コンセンサスのImmunoscoreアッセイは,腫瘍に浸透するT細胞を評価する.

研究の目的

Immunoscoreアッセイを用いて,全体および細胞毒性腫瘍浸透性T細胞数の予後値を評価する.
ステージI-IIIの結腸がん患者の免疫スコアの有用性を評価する.

主な方法

国際的なコンソーシアムは13カ国で Immunoscore 試験を評価した.
腫瘍サンプルにおけるCD3+およびCD8+T細胞の免疫ヒストキミストリー定量化.
デジタル病理学では T細胞密度から免疫スコアを得ました

主要な成果

Immunoscoreアッセイは,観察者およびセンター間で高い再現性を示した.
高いImmunoscoreは5年後に再発するリスクが有意に低下した (HR 0. 20,p< 0. 0001).
予後値は臨床的要因とは無関係で,TNM段階測定よりも優れていた.

結論

Immunoscoreは結腸癌の再発リスクの信頼性の高い見積もりを提供します.
結果は,TNM-Immune分類システムでImmunoscoreを実装することを支持しています.

大腸がんの分類のためのコンセンサスのImmunoscoreの国際的検証:予測と精度に関する研究

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大腸がんの分類のためのコンセンサスのImmunoscoreの国際的検証:予測と精度に関する研究

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まとめ

科学分野

背景

研究 の 目的

主な方法

主要な成果

結論

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