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Updated: Feb 10, 2026

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
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薬剤耐性 メラノーマ の 治療 可能性 を 持つ 既得 脆弱 性

Liqin Wang1, Rodrigo Leite de Oliveira1, Sanne Huijberts2

  • 1Division of Molecular Carcinogenesis, Oncode Institute, the Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.

Cell
|May 15, 2018
PubMed
まとめ

薬剤耐性メラノーマは反応性酸素種 (ROS) に脆弱性を発達させる. ヴォリノスタットによる治療は,これらの抵抗性細胞を選択的に標的とし,BRAF+MEK阻害剤に抵抗性のあるメラノーマに対する新しい治療戦略を提供します.

キーワード:
HDAC 阻害剤薬剤耐性メラノーマ反応性酸素種

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