エピジェネティック継承における液体型の凝縮物の時空調節

Gang Wan¹, Brandon D Fields^1,2, George Spracklin^1,2

¹Department of Genetics, Harvard Medical School, Boston, MA, USA.

Nature

|May 18, 2018

まとめ

研究者はC. elegansの生殖細胞で新しい生物分子凝縮物であるZ粒子を発見しましたこれらのZ粒子は,P粒子とともに,RNA指向の世代を超えた表遺伝子遺伝に不可欠である.

科学分野:

細胞生物学
遺伝学
分子生物学

背景:

膜に結合しない臓器は,タンパク質とRNAの自発的な自己組織化によって形成されます.
これらの生物分子凝縮物の形成と相互作用のメカニズムは,まだ十分に理解されていません.

研究の目的:

胚粒子の形成と機能に関与するタンパク質を特定する.
新型コンデンサートのダイナミックな組み立てと生物学的役割をC.elegansの生殖系で調査する.

主な方法:

C. elegansの生殖系におけるZNFX-1およびWAGO-4タンパク質の局所化研究
発芽期のコンデンサート動態の観察
静止RNAとのZNFX-1とWAGO-4の相互作用の分析

主要な成果:

ZNFX- 1とWAGO- 4のタンパク質は,最初はP粒に局所化し,後に独立したZ粒を形成する.
Z粒子は,P粒子とMutatorの焦点と組み合わされ,成体生殖細胞のPZM粒子を構成する.
ZNFX-1とWAGO-4は,静止RNAと相互作用して,世代を超えた表遺伝子遺伝を誘導する.

結論:

液体ドロップレットオルガネルの時間的および空間的な組織は,複雑なRNA処理経路を容易にする.
これらの発見は,RNAによって導かれた世代を超えた表遺伝子遺伝のメカニズムに光を当てる.

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