Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Social Scripts02:10

Social Scripts

10.3K
People tend to know what behavior is expected of them in specific, familiar settings. A script is a person’s knowledge about the sequence of events expected in a specific setting (Schank & Abelson, 1977). Essentially, scripts are a particular kind of schema, one containing default values for the features within an event. In the restaurant example, the script's features include the props (e.g., tables, menu, food, and money), the roles to be played (e.g., customer and waiter),...
10.3K
Social Proof00:52

Social Proof

32.4K
Social proof is a form of persuasion based on comparison and conformity. People compare their behavior and actions to what others are doing and will change to conform to do what their peers do.
32.4K
Distribution of Stresses in a Narrow Rectangular Beam01:11

Distribution of Stresses in a Narrow Rectangular Beam

546
In studying beam stress distribution, examining an elemental section is essential. To determine the average shearing stress on this face, the calculated shear is divided by the surface area. Importantly, shearing stresses on the beam's transverse and horizontal planes mirror each other, indicating a consistent stress distribution along the upper region of the beam. Notably, shearing stresses are absent at the beam's upper and lower surfaces due to the absence of applied forces in these...
546
Social Traps01:41

Social Traps

26.9K
Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned...
26.9K
Social Facilitation01:04

Social Facilitation

36.6K
Not all intergroup interactions lead to negative outcomes. Sometimes, being in a group situation can improve performance. Social facilitation occurs when an individual performs better when an audience is watching than when the individual performs the behavior alone. This typically occurs when people are performing a task for which they are skilled.
36.6K
Social Loafing01:37

Social Loafing

39.7K
Another way in which a group presence can affect performance is social loafing—the exertion of less effort by a person working together with a group. Social loafing occurs when our individual performance cannot be evaluated separately from the group. Thus, group performance declines on easy tasks (Karau & Williams, 1993). Essentially individual group members loaf and let other group members pick up the slack. Because each individual’s efforts cannot be evaluated,...
39.7K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Protein-guided RNA barcoding links transcriptomes to synaptic architecture.

bioRxiv : the preprint server for biology·2026
Same author

Crossing the finish line towards a disease-modifying treatment for Angelman syndrome.

Journal of neurodevelopmental disorders·2026
Same author

Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling.

Cell·2025
Same author

Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling.

bioRxiv : the preprint server for biology·2025
Same author

Author Correction: In vivo base editing extends lifespan of a humanized mouse model of prion disease.

Nature medicine·2025
Same author

In vivo base editing extends lifespan of a humanized mouse model of prion disease.

Nature medicine·2025

関連する実験動画

Updated: Feb 10, 2026

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
07:30

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

25.6K

神経ペプチド Tac2は,慢性的な社会的孤立ストレスによって引き起こされる分散した脳状態を制御する.

Moriel Zelikowsky1, May Hui1, Tomomi Karigo1

  • 1Division of Biology and Biological Engineering 156-29, California Institute of Technology, Pasadena, CA 91125, USA.

Cell
|May 19, 2018
PubMed
まとめ

慢性的な社会孤立ストレス (SIS) は,タキキニン2 (Tac2) /ニューロキニンB (NkB) を脳全体で向上させることでマウスの行動を変化させます. NkB受容体 (Nk3R) を阻害することで,これらの効果は逆転し,治療の可能性を示唆した.

キーワード:
BNST についてDMH についてNk3R についてNkB についてタック2攻撃性アミグダラ恐怖ニューロペプチド社会的孤立ストレス

さらに関連する動画

The Trier Social Stress Test Protocol for Inducing Psychological Stress
09:39

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

58.3K
A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits
08:10

A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits

Published on: November 24, 2015

20.9K

関連する実験動画

Last Updated: Feb 10, 2026

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
07:30

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

25.6K
The Trier Social Stress Test Protocol for Inducing Psychological Stress
09:39

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

58.3K
A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits
08:10

A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits

Published on: November 24, 2015

20.9K

科学分野:

  • 神経科学
  • 行動科学
  • 分子生物学

背景:

  • 慢性的な社会的孤立は人間に重大な心理的苦痛をもたらすが,その根底にある神経機構は完全に理解されていない.
  • 社会的孤立の神経生物学を理解することは 効果的な介入の開発に不可欠です

研究 の 目的:

  • マウスにおける慢性的な社会的孤立ストレス (SIS) によって引き起こされる行動変化の神経基礎を調査する.
  • SISの効果を媒介するタキニン2 (Tac2) /ニューロキニンB (NkB) システムの役割を調査する.

主な方法:

  • マウスにおける社会的孤立ストレス (SIS) の誘導は,期間が異なる (24時間対2週間).
  • ニューロキニン3受容体 (Nk3R) 抗剤の全身投与
  • NkB発現と放出の強化 グループに収容されたマウスで
  • 複数の脳領域における Tac2/NkB機能の複合分析

主要な成果:

  • 2週間のSISは 24時間ではなく 行動の変化と脳全体の Tac2/NkBの上昇を引き起こしました
  • Nk3Rアンタゴニストの投与は,SISによって引き起こされるほとんどの行動変化を予防しました.
  • 攻撃性を促進し 防御的行動を変化させた
  • Tac2/NkBとNk3Rは,異なるSIS誘発の行動変化を媒介する地域特有の役割を示した.

結論:

  • Tac2/NkBシグナリングは慢性的な社会的孤立ストレスに対する行動的および神経的適応の重要な媒介です.
  • Tac2/NkBシステムは,SISへの応答を調整するために,複数の脳領域に分散的に作用します.
  • Nk3Rアンタゴニストは,社会的孤立に関連した状態に対する有望な治療戦略です.