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Updated: Feb 10, 2026

Genome-wide Profiling of Transcription Factor-DNA Binding Interactions in Candida albicans: A Comprehensive CUT&RUN Method and Data Analysis Workflow
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Genome-wide Profiling of Transcription Factor-DNA Binding Interactions in Candida albicans: A Comprehensive CUT&RUN Method and Data Analysis Workflow

Published on: April 1, 2022

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遺伝子 的 に 多様 な マクロファージ の 分析 に よっ て,転写 因子 の 結合 と 機能 を 制御 する 局所 的 と 領域 的 な 機構 が 明らか に なっ た

Verena M Link1, Sascha H Duttke2, Hyun B Chun2

  • 1Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA; Faculty of Biology, Division of Evolutionary Biology, Ludwig-Maximilian University of Munich, Munich, Germany.

Cell
|May 22, 2018
PubMed
まとめ

遺伝的変異は遺伝子発現と細胞現象に大きく影響する. この研究は,マウスの何百万もの遺伝的変異がマクロファージの転写因子結合と遺伝子調節に影響を及ぼし,遺伝子発現制御に関する新しい洞察を明らかにしています.

キーワード:
クロマチン構造シス規制領域景観を良くする遺伝子発現遺伝的変異マクロファージ転写因子結合

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Transcription Factors02:16

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Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
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