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Updated: Feb 10, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
06:06

In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

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ユカリオットのプロテオームは,C末端のデグロンを標的とするE3ウビキチンリガゼによって形成される

Itay Koren1, Richard T Timms1, Tomasz Kula1

  • 1Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

Cell
|May 22, 2018
PubMed
まとめ

科学者たちは新しい方法で 重要なタンパク質のレギュレーターである 何千もの新型デグロンを発見しました 多くのデグロンはタンパク質のC端に存在し,新しい"C端規則"がタンパク質の安定性と細胞タンパク質を支配することを示唆している.

キーワード:
C 終点CRLクリン下降するE3ユビキチンリガゼGPS についてデグロン全体のタンパク質の安定性タンパク質の分解ユビキチネーション

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