体は瞬間の行動選択によって3Dの行動を組織する
Jeffrey E Markowitz1, Winthrop F Gillis2, Celia C Beron1
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Cell
|May 22, 2018
まとめ
研究者らはマウスの背側線状組織 (DLS) が 異なる神経経路のダイナミクスを用いて 連続的な行動をコードし組み立てていることを発見しました この脳の領域は 基本的な要素から 複雑な行動を構築するのに 極めて重要です
科学分野:
- 神経科学
- 行動科学
- 計算神経科学
背景:
- 自然主義的な行動は 連続した行動モジュールで構成されています
- ドルソラテラル・ストライアタム (DLS) は行動選択に関与しているが,制御されていない動物の複雑な行動のシーケンスにおけるその役割は不明である.
研究 の 目的:
- DLSにおける連続的な行動の構成の基礎となる神経機構を調査する.
- DLSのニューラル活動が 行動要素とその時間的な順序をどのようにコードするかを理解するためです
主な方法:
- DLSの直接的・間接的な経路で,マウスの自発的な行動で記録された大量および細胞神経活動.
- 3Dのモーショントラッキングを使って 副秒間の行動パターンを分析した
- シーケンスアセンブリへの影響を評価するためにDLSの損傷を行った.
主要な成果:
- DLSニューロンは 3D行動モチーフのアイデンティティと順序をコードします
- 直接的な経路と間接的な経路の間の迅速な時間スケールによる関連性は,このエンコーディングを容易にする.
- DLSの病変は 探索や匂いを誘発する行動における 行動配列の組み立てを損ねました
結論:
- DLSは直接的・間接的な経路で 互補的なダイナミクスを利用し 基本的な3Dポーズダイナミクスの 神経コードを作成します
- DLSは,モジュール構成要素から有意義な行動シーケンスを構築する上で重要な役割を果たします.
- 神経回路が 時間の経過とともに 行動を形作るモデルを示唆しています
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