オルガノカタリティック・エナチオセレクティブ・コンストラクション・オブ・アキシアル・キラル・スルフォン・コンテインティング・スタイレン
Shiqi Jia1, Zhili Chen1, Nan Zhang1
1Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences , Chongqing University , Chongqing 401331 , P. R. China.
Journal of the American Chemical Society
|May 22, 2018
まとめ
この研究は,高い選択性を持つキラル・スルフォン・スタイレンを作るための有機触媒的方法を導入する. これらの化合物は,非対称な触媒に有用なリガンドに変換できます.
科学分野:
- 有機化学
- 非対称な触媒
- 器官触媒
背景:
- 軸性キラル化合物は,非対称合成における重要な構成要素である.
- これらのキラル・スケーファッドの建設に有効な方法を開発することは依然として大きな課題です.
- 硫黄を含有する分子は独特の電子とステリック特性を有する.
研究 の 目的:
- 軸性キラル型硫黄含有ステロンの新型有機触媒的エナンチオ選択合成を開発する.
- これらのキラル・スタイレンの 潜在的応用を探求する.
主な方法:
- エナチオセレクティブ合成のための有機触媒的アプローチを使用した.
- 立体化学を制御するために非対称な触媒を用いた.
- 合成されたスタイレンを機能的リガンドに変換することを研究した.
主要な成果:
- 硫黄を含有する様々な軸性キラルスタイレンを 合成した.
- 優れたエナチオ選択性 (最大99% ee) を達成した.
- 高いE/Z選択性 (>99%E/Z) が得られた.
結論:
- 開発された方法は,価値あるキラル・スルフォン・スタイレンに効率的にアクセスできます.
- これらのスタイロンは,リン酸とS/Pリガンドの多用途前駆体として機能する.
- その結果得られるリガンドは,有機触媒と非対称触媒の応用の可能性を示している.
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