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チェレーションによるC−C結合割れによるアルキニル化
Shunsuke Onodera1, Soya Ishikawa1, Takuya Kochi1
1Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
Journal of the American Chemical Society
|May 23, 2018
まとめ
研究者らは,アルリルベンゼン誘導体におけるアルリル基をアルケニル基に変換するための新しいロジウム触媒方法を開発した. スタイレンと誘導基を用いたこの効率的なアルケニル化プロセスは,プレニル化フェノールからアニリンへの新しい変換を可能にしました.
科学分野:
- 有機化学
- カタリシス
- 合成方法論
背景:
- アルリルベンゼン系は重要な有機構造である.
- C−C結合の直接的機能化は,有機合成における重要な課題である.
- アルケンの合成のための効率的な触媒方法の開発は極めて重要です.
研究 の 目的:
- アリル基をアルケニル基に直接変換するための新しいロジウム触媒法について報告する.
- 誘導基を持つスタイレンを用いてアルケニル化を行う.
- オーソプレニル化フェノルをアニリン衍生物に変換するための新しいプロトコルを開発する.
主な方法:
- ロージウム触媒によるC−C結合分裂による直接アルケニル化.
- ピリジルとピラゾリル群をアルリルベンゼンの指向群として利用する.
- オーソプレニル化フェノールからアニリンへの変換のための新しいプロトコルの開発
主要な成果:
- 様々なアルリルベンゼン誘導体の効率的なアルケニル化がスタイレンで達成された.
- この方法は,ピリジルおよびピラゾリル誘導基の存在で高い効率性を示した.
- オーソプレニル化フェノルをアニリンに変換するための新しいプロトコルが開発されました.
結論:
- 報告されたロジウム触媒による方法は,アルリルベンゼンの直接アルケニル化のための新しい経路を提供します.
- 誘導群を使用すると,アルケニル化プロセスの効率が向上する.
- 開発されたプロトコルは,フェノール前駆体からアニリン誘導体の合成の可能性を拡大します.
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