トリフローロメチルベンゾアート:多用途のトリフローロメトキシル化反応剤
Min Zhou1, Chuanfa Ni1, Yuwen Zeng1
1Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry , University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Ling-Ling Road , Shanghai 200032 , China.
Journal of the American Chemical Society
|May 23, 2018
まとめ
新しい反応剤であるトリフローロメチルベンゾ酸 (TFBz) は,効率的なトリフローロメトキシル反応を可能にします. 簡単に合成され,様々な有機変換で幅広い合成有用性を示しています.
科学分野:
- 有機化学
- 合成化学
背景:
- トリフローロメトキシル化は,医薬品と材料化学における重要な変換である.
- 安定した,アクセス可能なトリフオロメトキシル化反応剤の開発は,引き続き活発な研究分野です.
研究 の 目的:
- 耐久性の高い新型トリフローロメトキシル化反応剤の開発
- 様々な有機反応における新反応物の 合成の多用途性を示します
主な方法:
- KFを用いた安価な前体からトリフローロメチルベンゾアート (TFBz) を合成する.
- TFBzの適用は,アリンのトリフローロメトキシル化-ハロゲン化,核愛的置換,クロスカップリング,アルケンの二機能化.
主要な成果:
- トリフローロメチルベンゾアート (TFBz) の合成が成功し,耐久性が実証されました.
- 反応剤は,室温でアリンを前例のないトリフローロメトキシル化-ハロゲン化を含む様々な反応で効率的なトリフローロメトキシル化を促進しました.
- アリルスタナンとクロスカップリングに成功し,アルケンの非対称的な機能化は達成された.
結論:
- トリフローロメチルベンゾアート (TFBz) は,トリフローロメトキシ基を導入するための価値のある多用途反応剤である.
- 調製の容易さと安定性により,トリフローロメトキシル化反応の魅力的な代替品となります.
- TFBzの開発は,合成化学者のツールキットを拡張し,特にフッ素化有機化合物の合成に役立ちます.
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