高放射性自己組み立てBODIPY-プラチナ超分子三角形
Jiong Zhou1,2, Yuzhen Zhang2, Guocan Yu1,3
1State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance and Novel Materials, Department of Chemistry , Zhejiang University , Hangzhou 310027 , P. R. China.
Journal of the American Chemical Society
|May 23, 2018
まとめ
BODIPYリガンドを持つ2つの新しいプラチナ (II) 超分子調整複合体 (SCC) は強力な抗がん活性を示しています. これらのセラノスティック剤は化学療法と光ダイナミック療法 (PDT) を組み合わせて,薬剤耐性がん細胞に対してさえ有効性を高めます.
科学分野:
- 超分子化学
- 材料科学
- 化学生物学
背景:
- 超分子調整複合体 (Supramolecular coordination complexes,SCC) は,化学および生物学的応用において価値あるものである.
- プラチナ ((II) 基化合物は,その治療的可能性のために広く研究されています.
- BODIPY染料は,優れた光と光動的特性を持っています.
研究 の 目的:
- BODIPYリガンドを用いた新しいプラチナ (II) 超分子三角形を合成し,特徴づけること.
- 抗がん活動とセラノスティックの可能性を評価する.
- 薬剤耐性がん細胞系に対する有効性を調べるため
主な方法:
- プラチナ (II) とBODIPYリガンドの協調制御による自己組み立て.
- HeLaとA2780cisの細胞系に対するin vitro抗癌活性測定
- 細胞内可視化のためのコンフォカル顕微鏡
- シネージ効果を評価するための組み合わせインデックスの計算
主要な成果:
- 2つの高放射性プラチナ (II) 超分子三角形 (1と2) が成功して合成されました.
- 両方の複合体は,HeLa細胞に対する有意な抗癌作用を示した.
- 複合体は細胞内可視化を可能にし,化学療法と光ダイナミック療法 (PDT) で相乗効果を示した.
- シスプラチン耐性A2780cis細胞に対して優れた有効性が認められ,薬剤耐性を克服する可能性を強調した.
結論:
- 開発されたプラチナ ((II) -BODIPY SCCは,化学療法とPDTを組み合わせた効果的なセラノスティック剤です.
- これらの複合体はプラチナの薬剤耐性を克服する 可能性を示しています
- 治療効果を最適化するために構成要素を独立して調整できます.
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