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Area Computation by the Alternative Coordinate Method01:24

Area Computation by the Alternative Coordinate Method

654
The alternative coordinate method, also known as the Shoelace Formula, is a technique for determining the area of a traverse using Cartesian coordinates. This method relies on the sequential arrangement of x and y coordinates for each point of the shape, ensuring accuracy and ease of application.In this approach, each corner's x and y coordinates are listed as fractions, with the x-coordinate as the numerator and the y-coordinate as the denominator. These coordinates are arranged sequentially...
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Stokes' Law01:20

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Viscous forces, like friction, are intermolecular forces that resist the relative motion of molecules over each other. When a solid body moves through a liquid, viscous forces drag it in the opposite direction. The force's magnitude depends on the solid's shape and size, as well as its speed and the liquid's coefficient of viscosity, density and temperature.
The expression for the force on a solid spherical object in a fluid is called Stokes' law. Stokes' law is valid only...
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In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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Divergence and Stokes' Theorems01:06

Divergence and Stokes' Theorems

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The divergence and Stokes' theorems are a variation of Green's theorem in a higher dimension. They are also a generalization of the fundamental theorem of calculus. The divergence theorem and Stokes' theorem are in a way similar to each other; The divergence theorem relates to the dot product of a vector, while Stokes' theorem relates to the curl of a vector. Many applications in physics and engineering make use of the divergence and Stokes' theorems, enabling us to write...
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For incompressible Newtonian fluids, where density remains constant, stresses show a linear relationship with the deformation rate, defined by normal and shear stresses. Normal stresses depend on the pressure exerted on the fluid and the rate of deformation in specific directions, which determines how fluid flows under varying pressures. Shear stresses, on the other hand, act tangentially across fluid layers. They explain how adjacent fluid layers slide relative to one another, connecting...
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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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交互に振動する構造を導入することによってストークのシフトを増加させる一般的な方法

Tian-Bing Ren1, Wang Xu1, Wei Zhang1

  • 1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 , P.R. China.

Journal of the American Chemical Society
|May 25, 2018
PubMed
まとめ
この要約は機械生成です。

研究者らは光染料を改良する 新しい方法を開発し ストークスシフトを大幅に増やし 画像の質を向上させました この進歩は信号を強め 生物医学研究への応用のために 自動消火を減少させます

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Differential Imaging of Biological Structures with Doubly-resonant Coherent Anti-stokes Raman Scattering CARS

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関連する実験動画

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科学分野:

  • バイオメディカルイメージング
  • 有機化学
  • 材料科学

背景:

  • 商業的に利用可能な光染料は,しばしば小さなストークスシフトを有し,信号対ノイズ比が低く,自己消しになります.
  • 現在の顕微鏡の構成は,既存の光体の性質によって制限され,先進的なイメージング技術を阻害しています.

研究 の 目的:

  • 一般的なフッ素素のストークスシフトを大幅に増加させるための一般化可能な方法を開発する.
  • 既存の商用染料のイメージング効率と光安定性を向上させる.

主な方法:

  • 1,4-デチルデカヒドロキノキサリン (DQ) を光体の結合構造に添加する.
  • ストークスシフト,放出波長,および11種類のフッ素体における光安定性に対するDQ部分の影響を評価.

主要な成果:

  • DQ分子は,ストークスシフト,放出波長,および11のフッ素素の光安定性を3倍以上成功的に拡大しました.
  • ヘミシアニンのDQ誘導体は,インドシアニングリーンと比較してマウスモデルで5倍信号の増加を示した.
  • DQで修正されたフッ素は,単発,多発性イメージングを通じて,堅固な細胞行動研究を可能にしました.

結論:

  • 開発された方法は,商用フッ素素の性能を高めるために一般化可能なアプローチを提供します.
  • 超高解像度顕微鏡と第2のウィンドウ近赤外線画像に期待できる染料です
  • この技術は,様々な生物医学イメージングのアプリケーションで,信号対ノイズ比を大幅に改善し,自己消耗を減らすことができます.