Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Switching of BJT01:22

Switching of BJT

873
Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
Cut-off Mode ("Off" State): In this state, both the emitter-base and collector-base junctions are...
873
What is Natural Selection?01:32

What is Natural Selection?

129.7K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.7K
Antibiotic Selection00:57

Antibiotic Selection

60.1K
Overview
60.1K
Types of Selection01:46

Types of Selection

45.3K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
45.3K
Persuasion Strategies01:52

Persuasion Strategies

43.5K
Researchers have tested many persuasion strategies, including the foot-in-the door and the door-in-the-face techniques, in a variety of contexts. Ultimately, the principles are effective in selling products and changing people’s attitude, ideas, and behaviors (Cialdini & Goldstein, 2004).
43.5K
Frequency-dependent Selection01:21

Frequency-dependent Selection

24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Phosphonium Ions as Activating Groups for the Selective Alkylation of Pyridines and Polyazines.

Journal of the American Chemical Society·2026
Same author

Potassium Bisulfite's Role in Developing a Robust Platform for Enantioenriched <i>N</i>-Alkylpyridinium Salts as Piperidine Precursors.

Journal of the American Chemical Society·2026
Same author

Stable Isotope Labeling of Pyrimidines Using a Deconstruction-Reconstruction Strategy.

Journal of the American Chemical Society·2025
Same author

A Broadly Applicable Strategy to Aminate Azines Enabled by Electronically Tuned Phosphine Reagents.

Angewandte Chemie (International ed. in English)·2025
Same author

3-Selective Pyridine Fluorination via Zincke Imine Intermediates.

Journal of the American Chemical Society·2025
Same author

A deconstruction-reconstruction strategy for pyrimidine diversification.

Nature·2024

関連する実験動画

Updated: Feb 10, 2026

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.7K

ポリアジンを機能化するためのサイト選択的な切り替え戦略

Ryan D Dolewski1, Patrick J Fricke1, Andrew McNally1

  • 1Department of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , United States.

Journal of the American Chemical Society
|May 25, 2018
PubMed
まとめ

研究者は,ポリアジン構造におけるC−H結合を選択的に機能化するための新しい方法を開発し,価値ある薬物誘導体のより簡単な合成を可能にしました. このサイト選択型フォスフォニウムイオン装置は,医薬品化学の用途に多用途なハンドルを提供しています.

科学分野:

  • 有機化学
  • 薬剤化学
  • 合成化学

背景:

  • 複数のピリジンとディアジン環を含むポリアジン構造は,薬物の断片と治療用化合物で一般的です.
  • これらの複雑な分子におけるC−H結合変換のための部位選択反応の開発は,誘導体の効率的な合成に不可欠である.

研究 の 目的:

  • ポリアジン構造にフォスフォニウムイオン機能ハンドルを場所選択的に設置するための新しい方法を提示する.
  • 場所選択性を制御する要因を記述し,選択性を切り替えるための機械的に駆動されたアプローチを示します.

主な方法:

  • フォスフォニウムイオン装置を使用した選択的なC-H結合機能化.
  • ポリアジンシステムにおけるサイト選択性を支配する固有要因の調査.
  • 機能化の場所の予測可能な切り替えを可能にするメカニズム研究.

主要な成果:

  • フォスフォニウムイオン (C-+PPh3) を多機能ハンドルとして成功裏に選択的に設置.
  • 反応の部位選択性を制御する重要な要因の特定.
  • 予測可能なサイト選択スイッチングのための機械的に駆動されたアプローチの実証.

さらに関連する動画

Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection
08:37

Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection

Published on: December 10, 2015

19.9K
Measuring the Switch Cost of Smartphone Use While Walking
07:00

Measuring the Switch Cost of Smartphone Use While Walking

Published on: April 30, 2020

2.3K

関連する実験動画

Last Updated: Feb 10, 2026

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
12:31

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

15.7K
Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection
08:37

Measurement of H2S in Crude Oil and Crude Oil Headspace Using Multidimensional Gas Chromatography, Deans Switching and Sulfur-selective Detection

Published on: December 10, 2015

19.9K
Measuring the Switch Cost of Smartphone Use While Walking
07:00

Measuring the Switch Cost of Smartphone Use While Walking

Published on: April 30, 2020

2.3K

結論:

  • 開発された方法は,薬剤化学者が貴重なポリアジン誘導体にアクセスするためのシンプルで魅力的なアプローチを提供します.
  • シンプルなプロトコルと容易に入手可能な試薬は,複雑な薬のような分子にこの技術の適用を容易にする.