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Updated: Feb 10, 2026

Formaldehyde-assisted Isolation of Regulatory Elements to Measure Chromatin Accessibility in Mammalian Cells
08:08

Formaldehyde-assisted Isolation of Regulatory Elements to Measure Chromatin Accessibility in Mammalian Cells

Published on: April 2, 2018

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CTCF結合要素は,クロマチンスキャン中にRAG基板のアクセシビリティを媒介する.

Suvi Jain1, Zhaoqing Ba1, Yu Zhang1

  • 1Howard Hughes Medical Institute; Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Cell
|May 29, 2018
PubMed
まとめ

CTCF結合要素 (CBEs) は,抗体V(D) J再結合部位の近くで,V(D) J再結合効率を高めています. これは予期せぬクロマチンのアクセシビリティ機能によって,特にIGCR1制御領域が不活性であるときに起こります.

キーワード:
3C-HTGTSCBEの指針CTCFの拘束要素HTGTS-Rep-seq についてRAGクロマチンスキャンV(D) J 再結合アクセシビリティV (H) 81X について遺伝子間制御領域 1ループの流出

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