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Updated: Feb 10, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

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エッジホッグシグナリングにおける滑らかなアクティベーションの構造的基礎

Pengxiang Huang1, Sanduo Zheng2, Bradley M Wierbowski1

  • 1Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

Cell
|May 29, 2018
PubMed
まとめ

コレステロールとスムージド (SMO) の結合は,システインに富んだドメイン (CRD) の方向転換によってヘッジホッグのシグナリングを活性化します. この構造の変化は阻害的な鎖を壊し,ステロールの移動と受容体の活性化のための経路を開きます.

キーワード:
エジホグ滑らかになった癌についてコレステロールシリア膜腫瘍遺伝子シグナリング

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