作者 訂正: Bリンパ性転写因子の代謝ゲートキーパー機能
Lai N Chan1,2, Zhengshan Chen1,2, Daniel Braas3
1Department of Systems Biology, Beckman Research Institute and City of Hope National Medical Center, Pasadena, California, 91016, USA.
Nature
|June 1, 2018
まとめ
白血病細胞におけるCRISPR-Cas9遺伝子の欠損を詳細に記述した手紙の図は修正されています. 誤りは誤ったデータですが,研究の結論には影響はありません.
科学分野:
- 遺伝学とゲノミクス
- 腫瘍学
- 細胞生物学
背景:
- CRISPR-Cas9の遺伝子編集は 遺伝子機能を調査する強力なツールです
- B系白血病は重大な血液学的悪性腫瘍である.
- NR3C1,TXNIP,CNR2は細胞プロセスや病気に関心のある遺伝子です.
研究 の 目的:
- 患者由来B系白血病細胞におけるNR3C1,TXNIP,CNR2遺伝子の削除の影響を調査する.
- 科学的再現性のために透明で正確なデータ表現を提供すること.
主な方法:
- CRISPR-Cas9による遺伝子消去
- 患者からのB系白血病細胞の分析
- 透明性のために数字の修正と補足データ提供.
主要な成果:
- 図3cのデータプロットは誤ってNR3C1データとTXNIPデータで置き換えられた.
- この数字はオンラインで修正され,元の数字は補足情報として提供されました.
- 特定された誤りは,研究の元の結論を変更しません.
結論:
- 図3cのデータプロットエラーにもかかわらず,手紙の科学的結論は有効です.
- 修正された数字と補足された情報源により,データの透明性が向上します.
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