インターニューロン生存の皮質ネットワークのピラミッド細胞調節
Fong Kuan Wong1,2, Kinga Bercsenyi1,2, Varun Sreenivasan1,2
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Nature
|June 1, 2018
まとめ
ピラミッド細胞活動は,出生後の重要な発達期間の抑制性内ニューロンの生存を調節する. この活動に依存するプロセスは,発達中の脳皮質の刺激性および抑制性ニューロンの正しいバランスを確保します.
科学分野:
- 神経科学
- 発達生物学
- 細胞生物学
背景:
- 哺乳類の脳皮質は 刺激神経と抑制神経のバランスの取れたネットワークに依存しています
- 発達中のこれらのニューロン集団の適切な数の確立を制御する正確なメカニズムは完全に理解されていません.
研究 の 目的:
- 産後発達中のインターニューロンの生存を調節するピラミッド細胞活動の役割を調査する.
- 活動に依存するニューロンの集団制御に関与する分子経路を解明する.
主な方法:
- 生後発達期における神経生存を研究するためにマウスモデルを使用した.
- 刺激性シナプス入力が個々のインターニューロン生存に与える影響を調査した.
- フォスファタゼとテンシンホモログ (PTEN) のシグナル伝達経路の調節を調査した.
主要な成果:
- ネズミの産後皮質の内ニューロンの生存は,ピラミッド細胞の活動に依存しています.
- 特定の発達期間のインターニューロンへの刺激性シナプスインプットは,その生存または死亡を予測します.
- ピラミッド細胞はPTENシグナル伝達を否定的に調節し,内部ニューロンの細胞死を促進する.
結論:
- 活動に依存するメカニズムは,発達する皮質回路における抑制性内ニューロンの数を動的に調節する.
- このプロセスは,脳皮質の刺激性ニューロンと抑制性ニューロンの 正確な比率を確立するために不可欠です.
- 発見は脳の発達初期に 活動に依存した回路の精錬のための新しいメカニズムを明らかにしています
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