波長選択光反応型DASA機能化されたポリマーナノ原子炉
Omar Rifaie-Graham1, Sebastian Ulrich1,2, Nikolas F B Galensowske1
1Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.
Journal of the American Chemical Society
|June 2, 2018
まとめ
研究者は,ドナー-受容体ステンハウスの誘導体 (DASA) を使用して光反応性ポリマーナノリアクターを開発した. これらのナノ炉は可視光で起動し 暗闇で不活性状態に戻し 制御された化学反応を可能にします
科学分野:
- 材料科学
- ポリマー化学
- ナノテクノロジー
背景:
- 光受容体は生化学的プロセスに 短時間的な光活性化を利用する.
- 人工ナノシステムは,制御された反応のための光反応性を模倣することを目指しています.
研究 の 目的:
- 可視光で切り替えるポリマーナノ原子炉を開発する.
- 暗闇の中での不活性状態に 素早く戻れるように
- 光制御による触媒と 荷重の解放を可能にします
主な方法:
- RAFTポリメリゼーションによるアンフィフィリックブロックコポリマーの合成.
- Meldrumの酸性またはピラゾロン性DASAで機能化しました.
- ポリマソームベシクルに自己組み立てられ,透かし性が制御されます.
主要な成果:
- ポリマーソームは,光によって誘発されたペイロードの放出を示し,光を取り除く時に停止した.
- ナノリアクターのカプセル化された酵素は,可視光照射下でのみ反応を触媒化します.
- 緑色と赤色の光に反応するナノ反応器の混合を用いて波長選択的触媒を達成した.
結論:
- DASAベースのナノ反応器は,光制御された膜透過性のための有望なプラットフォームを提供します.
- これらのシステムは,マイクロ流体および薬物投与における反応のオンデマンドスイッチングの可能性を示しています.
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