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Updated: Feb 9, 2026

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo
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Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo

Published on: July 25, 2025

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急性骨髄性白血病のCAR T細胞免疫療法を可能にするために,血液形成幹細胞におけるCD33の遺伝的不活性化

Miriam Y Kim1, Kyung-Rok Yu2, Saad S Kenderian3

  • 1Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Cell
|June 2, 2018
PubMed
まとめ

この研究では,血液形成性幹細胞がCD33マーカーを欠くように設計され,標的治療に対する耐性を生み出しました. このアプローチは,有害な副作用を予防しながら,キメリック抗原受容体T細胞による効果的な急性骨髄性白血病の治療を可能にします.

キーワード:
CD33 についてCRISPR/Cas9遺伝子編集急性骨髄性白血病キメリック抗原受容体T細胞ヘマトポエシス免疫療法人間以外の霊長類の血液形成

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