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Updated: May 10, 2026

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts
11:19

Merging Absolute and Relative Quantitative PCR Data to Quantify STAT3 Splice Variant Transcripts

Published on: October 9, 2016

エクソンスプライシングの複雑な組み合わせパターンは,単一の遺伝子から複数の調節されたトロポニンT同型を生成します

R E Breitbart, H T Nguyen, R M Medford

    Cell
    |May 1, 1985
    PubMed
    まとめ

    代替RNAスプライシングはタンパク質の多様性を生み出します. この研究は,ネズミの骨格の高速トロポニンT遺伝子における複雑なパターンを明らかにし,複雑なエクソンスプライシングを通じて複数のトロポニンT同型を生成し,組織特異的な機能に不可欠である.

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    RNA Splicing01:32

    RNA Splicing

    Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
    RNA Splicing01:32

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    Chromatin Structure Regulates pre-mRNA Processing

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    Alternative RNA Splicing

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    General Transcription Factors

    Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
    Alternative RNA Splicing02:18

    Alternative RNA Splicing

    Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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