ヒトの血タンパク質のゲノムアトラス
Benjamin B Sun1, Joseph C Maranville2,3, James E Peters1,4
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Nature
|June 8, 2018
まとめ
この研究はヒトの血タンパク質に 遺伝的影響をマッピングし 何千もの新しい関連性を発見しました これらの発見は,タンパク質レベルと疾患を結びつけ,潜在的な薬物標的と安全性に関する洞察を特定しています.
科学分野:
- 遺伝学
- プロテオミクス
- システム生物学
背景:
- 血タンパク質の個体間変動は十分に理解されていません.
- 血タンパク質は生物学的プロセスと 薬物の標的化に不可欠です
研究 の 目的:
- ヒトの血タンパク質の 遺伝子構造を特徴づけるため
- タンパク質のレベルや 生物学的経路や病気に 遺伝的多様性を結びつけるため
- 潜在的治療目標と薬物再利用の機会を特定する.
主な方法:
- INTERVAL研究からの健康な献血者における遺伝的関連性の分析
- 遺伝子データを経路,疾患,薬物のデータベースと統合する.
- 病気におけるタンパク質バイオマーカーの因果関係を推測するメンデルのランダム化分析.
主要な成果:
- 1,478個のタンパク質の遺伝的関連が 1,927個見つかりました 知識が4倍になりました
- 1,104のタンパク質のトランス結合の発見
- タンパク質定量特征ロシ (pQTLs),遺伝子発現定量特征ロシ (eQTLs),および疾患関連ロシの重なりを示す.
- 病気におけるタンパク質バイオマーカーの因果関係に関する証拠
結論:
- 血のタンパク質濃度には遺伝的要因が大きく影響する.
- 血タンパク質は 遺伝的変異を病気と結びつける 重要な媒介体として機能します
- この研究は,新しい治療目標の特定と薬物の効果の理解のための基盤を提供します.
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