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Updated: Feb 9, 2026

CRISPR Guide RNA Cloning for Mammalian Systems
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カスケードとCas3によるRNA誘導DNA分解の構造基礎

Yibei Xiao1, Min Luo2, Adam E Dolan1

  • 1Department of Molecular Biology and Genetics, Cornell University, 253 Biotechnology Building, Ithaca, NY 14853, USA.

Science (New York, N.Y.)
|June 9, 2018
PubMed
まとめ

タイプI-EのCRISPR-Casシステムは カスケードとCas3を使って DNAを分解します Cryo-EM構造は,Cas3が標的を特定し,Cascadeが標的を特定した後にDNAを分解する方法を明らかにします.

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