TCR トランスジェニックマウスは,特徴的な脂肪レグ現象の段階的,多部位獲得を明らかにする
Chaoran Li1, Joanna R DiSpirito1, David Zemmour1
1Department of Microbiology and Immunobiology and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Cell
|June 12, 2018
まとめ
内臓脂肪組織 (VAT) の T (Treg) 調節細胞はユニークな機能を持っています. 新しいマウスモデルで このVAT Treg細胞の 発達と機能が明らかにされ 炎症と代謝制御の 洞察が得られました
科学分野:
- 免疫学
- 代謝に関する研究
- 細胞生物学
背景:
- 内臓脂肪組織 (VAT) には,異なる表型を持つ調節性T細胞 (Treg) が含まれています.
- これらのVAT Treg細胞は,局所および全身の炎症と代謝の調節に不可欠です.
- 彼らの起源と機能を理解することは 治療戦略の鍵です
研究 の 目的:
- VATTregの細胞の発展,依存関係,活動を調査する.
- VAT Treg細胞の機能におけるT細胞受容体特異性の役割を明らかにする.
- VAT Treg細胞における転写因子と受容体の新しい機能を明らかにする.
主な方法:
- 富んだVAT Tregsを持つT細胞受容体トランスジェニックマウスラインの生成
- トレグ細胞の由来,依存性,および活動に関する分析
- 転写因子 (Foxp3) と受容体 (インタールイキン-33受容体) の役割の調査.
主要な成果:
- VAT Treg細胞の発達におけるT細胞受容体特異性の重要な役割を確立した.
- VAT Tregsのトランスクリプション因子 Foxp3の新しい機能を発見しました.
- VAT Treg機能におけるインタールイキン-33受容体の細胞内的な役割が示された.
- VAT Treg セル生成の2段階のプロセスを詳細に説明しました.
結論:
- VAT Treg細胞のフェノタイプは,臓のプリミングとVATの微小環境のシグナルから得られます.
- Foxp3とIL-33RのようなTreg細胞受容体の特異性と重要な分子プレーヤーは,その機能に不可欠です.
- 組織Treg生物学原理の解明は,代謝および炎症性疾患の標的治療の開発に不可欠です.
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