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Updated: Feb 9, 2026

Anaerobic Protein Purification and Kinetic Analysis via Oxygen Electrode for Studying DesB Dioxygenase Activity and Inhibition
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ヒトインドレアミン2,3ダイオキシゲネーゼ1の抑制メカニズム

Ariel Lewis-Ballester1, Shay Karkashon1, Dipanwita Batabyal

  • 1Department of Physiology and Biophysics , Albert Einstein College of Medicine , Bronx , New York 10461 , United States.

Journal of the American Chemical Society
|June 14, 2018
PubMed
まとめ

ヒューマンインドレアミン2,3-二酸化酵素1 (hIDO1) とトリプトファン二酸化酵素 (hTDO) は,構造的に類似しているが,抑制結合部位では異なっている. 研究者らは,トリプトファンまたは変異によってこの部位を遮断すると,hIDO1の活性が抑制され,3インドルエタノール (IDE) によって逆転することがわかった.

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