交差するメモリエングラムのアイデンティティのシナプス固有の表現
Kareem Abdou1,2, Mohammad Shehata1,2, Kiriko Choko1,2
1Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
Science (New York, N.Y.)
|June 16, 2018
まとめ
脳は繋がった記憶のために 共有された細胞ネットワークを使用しますが 個々の記憶のアイデンティティを維持するために シナプス特有の可塑性に依存しています この研究は 異なる記憶が 同じニューラル回路内で 保存され 復元される方法を 明らかにしています
科学分野:
- 神経科学
- 記憶に関する研究
- 細胞の可塑性
背景:
- 記憶は相互に繋がるネットワークを形成しますが 個々の記憶は 独特のアイデンティティを保持しています
- 共有された細胞集団内の個々の記憶の分離の基礎となる 神経機構は不明のままです
研究 の 目的:
- 脳が記憶を 共有する神経回路の中で 区別し 保存する方法を調査する
- 記憶結合とアイデンティティにおけるエングラム細胞とシナプス可塑性の役割を明らかにする.
主な方法:
- マウスの視力遺伝学を使って 聴覚的な恐怖を制御した 記憶のエングラムを 横側杏仁核で操作した
- 逆行性記憶喪失と標的型シナプス可塑性変化を誘発した後の記憶回復の評価
主要な成果:
- 恐怖記憶の完全な記憶喪失は 同じニューラル・アンサンブルを共有する 関連した記憶に影響を与えませんでした
- 特定のシナプスの可塑性の 光遺伝的操作は 標的記憶のリコールのみに影響します
- エングラム細胞の共有は記憶の連結の基礎であり,シナプス特有の可塑性は個々の記憶のアイデンティティを保証します.
結論:
- 記憶の連結は 神経ネットワーク内のエングラム細胞の共有によって媒介されます.
- シナプス特有の可塑性は 個々の記憶の独特のアイデンティティと 記憶の保存に不可欠です
- 脳が多重で相互に関連した記憶を 管理する方法の枠組みです
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