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Updated: Feb 8, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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CDK12の不活性化により,前立腺がんの独特の免疫性分類が示される

Yi-Mi Wu1, Marcin Cieślik1, Robert J Lonigro2

  • 1Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

Cell
|June 16, 2018
PubMed
まとめ

転移性離抵抗性前立腺がん (mCRPC) で,CDK12の損失を伴う新しい前立腺がんサブタイプが発見されました. このサブタイプは,遺伝子融合と高濃度のネオアンチゲンによって特徴付けられ,免疫チェックポイント免疫療法に反応する可能性があります.

キーワード:
CDK12 について焦点タンデム重複遺伝子融合免疫療法前立腺がんの転移ネオアンチゲン

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