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関連する概念動画

Elements and Compounds01:27

Elements and Compounds

105.1K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
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Periodic Classification of the Elements04:00

Periodic Classification of the Elements

59.3K
The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
59.3K
Peptide Bonds02:43

Peptide Bonds

83.3K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
83.3K
Classification of Elements and Compounds02:54

Classification of Elements and Compounds

73.3K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond. Elements are classified as atomic or molecular based on the nature of their basic units.
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
73.3K
Key Elements for Plant Nutrition02:35

Key Elements for Plant Nutrition

24.4K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.4K
Elements: Chemical Symbols and Isotopes02:31

Elements: Chemical Symbols and Isotopes

126.6K
A chemical symbol is an abbreviation used to indicate an element or an atom of an element. For example, the symbol for mercury is Hg. The same symbol is used to indicate one atom of mercury (microscopic domain) or to label a container of many atoms of the element mercury (macroscopic domain).
Some symbols are derived from the common English name of the element; others are abbreviations of the name in another language — Latin, Greek or German. For example, the symbol for aluminum (common name)...
126.6K

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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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ペプチドマクロサイクルのための内循環制御要素の開発

Solomon D Appavoo1, Takuya Kaji1, John R Frost1

  • 1Davenport Research Laboratories, Department of Chemistry , University of Toronto , 80 St. George Street , Toronto , Ontario M5S 3H6 , Canada.

Journal of the American Chemical Society
|June 20, 2018
PubMed
まとめ

研究者は,縮小されたアミド結合/ヘテロサイクル (RAH) モチーフを使用して,周期性ペプチド構成を安定させる新しい方法を開発した. このアプローチにより,α4β7インテグリンを標的とする新しい分子が発見されました.

科学分野:

  • 薬剤化学
  • 有機合成
  • 構造生物学

背景:

  • マクロサイクルの形状を制御することは 生物活性分子を発見するのに不可欠です
  • ヘテロサイクルをサイクルペプチドに組み込むことは,その構造を安定させることができます.
  • 形状制御のための方法の開発は,分子設計における課題に対応しています.

研究 の 目的:

  • N- ((イソシアニミノ) トリフェニルフォスフォラン (Pinc) を使用してオクサジアゾール環とエンドサイクルアミンを合成する.
  • 周期性ペプチドにおける新しい減少アミド結合/ヘテロサイクル (RAH) モチーフの構成効果を調査する.
  • 生物学的構造を模倣し,新たな薬剤候補を発見する際にRAHモチーフの有用性を探求する.

主な方法:

  • オキシジアゾール環を組み込んだペプチドマクロサイクルを合成する.
  • 変数温度核磁気共鳴 (NMR) 分析
  • 核オーバーハウザー効果 (NOE) ベースの分子ダイナミクスシミュレーション
  • 水分とDMSOの両方の溶液における適合性分析

主要な成果:

  • 縮小されたアミド結合/ヘテロサイクル (RAH) モチーフはペプチドマクロサイクルに成功しました.

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Mechanical Manipulation of Neurons to Control Axonal Development
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Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
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  • RAHモチーフは,水とDMSOの両方でマクロサイクル構造を安定させる能力を示した.
  • 溶液構造はRAHモチーフの形状安定効果を確認した.
  • RAHの構成効果は,MAdCAM-1の二次構造を模倣するために利用されました.
  • 結論:

    • RAHモチーフは,溶液中のマクロサイクル構成を安定させるための貴重な戦略を提供します.
    • この安定化は 生物活性分子の 分子設計における 重要な課題に対応しています
    • この研究は,生物学的に重要な二次構造を模倣した新しいα4β7インテグリン対抗剤の発見をもたらした.