ストレス関連疾患と,その後の自己免疫疾患の関連
Huan Song1,2, Fang Fang2, Gunnar Tomasson3,4,5
1Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
JAMA
|June 21, 2018
まとめ
ストレス関連の障害を持つ人は 自己免疫疾患を発症するリスクが高くなります この関連性はスウェーデンのコホート研究で確認され,精神的健康と免疫系の機能の関連性を強調した.
科学分野:
- 精神科
- 免疫学
- 流行病学について
背景:
- ストレスに対する精神的反応は一般的であり 免疫機能障害につながる可能性があります
- ストレス関連疾患と自己免疫疾患のリスクとの関連はよくわかっていません.
研究 の 目的:
- ストレス関連の障害と,その後の自己免疫疾患の発症リスクとの関連を調査する.
主な方法:
- スウェーデンでの遡及的なコホート研究 (1981年−2013年) は,10万6000人以上のストレス関連疾患の患者と対照群を対象とした.
- ストレス関連の障害と41の自己免疫疾患の診断は,国家患者登録を通じて確認された.
- コックスモデルは,ストレス関連障害の診断後の自己免疫疾患の危険比率 (HRs) を推定した.
主要な成果:
- ストレス関連疾患を有する患者は,自己免疫疾患のリスクが著しく高かった (HR,1. 36).
- トラウマ後ストレス障害は,任意の (HR,1. 46) 及び複数の (HR,2.29) 自身免疫疾患のリスクを高めました.
- リスクの増加は若い患者でより顕著であり,SSRIの使用はリスクの軽減と関連していました.
結論:
- ストレス関連の障害は,その後の自己免疫疾患のリスクの増加と有意に関連しています.
- 結果は集団と同胞との比較で一致した.
- 基礎となる生物学的メカニズムを明らかにするためにさらなる研究が必要である.
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