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Updated: Feb 8, 2026

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
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A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

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スーパーエンハンスターでのコアクティベーター濃縮,相分離および遺伝子制御

Benjamin R Sabari1, Alessandra Dall'Agnese1, Ann Boija1

  • 1Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|June 23, 2018
PubMed
まとめ

スーパーエンハンサー (SE) は細胞のアイデンティティ遺伝子を駆動します BRD4とMED1のタンパク質はSEで液体状の凝縮体を形成し,転写機構を集中させ,遺伝子調節における本質的に乱れた領域の役割を強調する.

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