コメント "肺の免疫を消毒するには,真菌アポトーシスのようなプログラム細胞死を標的とする"

Abdel Aouacheria¹, Kyle W Cunningham², J Marie Hardwick³

¹ISEM, Institut des Sciences de l'Evolution de Montpellier, Université de Montpellier, CNRS, EPHE, IRD, Montpellier, France.

Science (New York, N.Y.)

|June 23, 2018

まとめ

アスペルギルス・フミガツ菌はヒト中性粒子が誘発したプログラム細胞死を受けない. プロテアゼシグナル伝達または真菌カスパース阻害剤の確認には,現在の証拠は不十分である.

科学分野:

菌類学
免疫学
細胞生物学

背景:

アスペルギルス・フミガトゥスは,人間にアスペルギロスを引き起こす一般的な真菌である.
肺中性粒子は真菌病原体における細胞死を誘発することが知られている.
以前の研究では,A. fumigatusにおけるカスパースに依存したアポトーシスのような細胞死が示唆された.

研究の目的:

肺中性粒子の相互作用により,アスペルギルス・フミガトゥスの細胞死亡のメカニズムを調査する.
菌細胞死がプロテアゼシグナルカスケードによって媒介されるかどうかを判断する.
ヒトの生存に同質なカスパース阻害体の役割を評価する.

主な方法:

シュレジンガーらによる研究特定の技術を使って菌類の細胞死を観察しました
分析はカスパース依存経路とプロテアースシグナル伝達に焦点を当てた.
カスパース抑制剤の効果を調べた

主要な成果:

研究によると,アスペルギルス・フミガタスはカスパースに依存したアポトーシスのような細胞死を経験しています.
この細胞死は肺中性粒子が引き起こすものです
しかし,真菌のカスパース阻害剤によって阻害されたプロテアゼシグナルカスケードの証拠は不確実であることが判明しました.

結論:

この発見は,アスペルギロシスの真菌細胞死に関する以前に報告されたメカニズムに疑問を投げかけています.
A. fumigatusの病原性におけるプロテアゼシグナル伝達と真菌カスパース阻害体の役割を確認するためにさらなる研究が必要である.
菌と宿主の相互作用を正確に調べるには信頼できる技術が不可欠です

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