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関連する概念動画

Shock Waves01:16

Shock Waves

2.6K
While deriving the Doppler formula for the observed frequency of a sound wave, it is assumed that the speed of sound in the medium is greater than the source's speed through it. When this condition is breached, a shock wave occurs.
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high...
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Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

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Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
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Milgram's Obedience to Authority02:20

Milgram's Obedience to Authority

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Obedience to authority is classically demonstrated in a more famous series of social psychology experiments performed by Stanley Milgram. He was a social psychology professor at Yale who was influenced by the trial of Adolf Eichmann, a Nazi war criminal. Eichmann’s defense for the atrocities he committed was that he was “just following orders.”
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Antibiotic Selection00:57

Antibiotic Selection

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Overview
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Bacterial Transformation01:33

Bacterial Transformation

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In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
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Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

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Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
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Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
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Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

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セプシスとセプティックショック

Maurizio Cecconi1, Laura Evans2, Mitchell Levy3

  • 1Department of Anaesthesia and Intensive Care, IRCCS Istituto Clinico Humanitas, Humanitas University, Milan, Italy.

Lancet (London, England)
|June 26, 2018
PubMed
まとめ
この要約は機械生成です。

生命を脅かす感染症であるセプシスには,臓器機能不全に焦点を当てた新しい定義 (セプシス-3) がある. 研究によりよい診断と治療が求められる一方で 基本的なケアと教育が改善されれば セプシスの治癒の鍵となるのです

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Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
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Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
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Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

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Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
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Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
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科学分野:

  • クリティカル ケア 医療
  • 感染症
  • 公衆衛生

背景:

  • セプシスは高い死亡率と発症率を伴う世界的な健康問題です
  • 過去10年にわたる意識と研究により 理解と成果が向上しました
  • 世界保健総会は 2017年にセプシスを世界保健の優先事項としました

研究 の 目的:

  • セプシスの現在の理解と管理を要約します.
  • セプシスの定義と進行中の研究方向の進化を強調する.
  • セプシスの管理における基本的なケア改善の重要性を強調する.

主な方法:

  • 最近の研究とセプシスの臨床ガイドラインのレビュー.
  • セプシス3の定義の影響分析
  • セプシスの診断と治療に関する現在と将来の研究について議論します.

主要な成果:

  • セプシス-3の定義 (臓器機能不全の感染) は,連続臓器不全評価スコアを使用して2016年に確立されました.
  • 分子プロファイルに基づくパーソナライズされた管理戦略に向けて研究が進んでいます.
  • 改善された診断技術と標的型薬剤は調査中です.

結論:

  • 先進的な診断と治療が求められている一方で,教育と品質改善プログラムを通じて基礎的ケアが強化されることが, 症の治療結果を改善する上で極めて重要です.
  • セプシス-3の定義は,セプシスを特定し管理するための標準化された枠組みを提供します.
  • より効果的なセプシス治療法の開発には 研究を継続することが不可欠です